The microemulsion system is turning to be more viscous with addition of water and thus may help in the slow diffusing of drug at infinite dilution. Schematic representation of a reverse micelle nanoparticle in a wo microemulsion. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of microemulsion factors affecting. Alternative names for these systems are often used, such as swollen micelle. The swollen micellemicroemulsion transition donald b. Effect of microemulsion on foam stability springerlink. Pdf from simple micelles in water, nearly spherical aggregates of amphiphilic molecules.
Surfactant, swollen micelle, microemulsion, solubilization. It has been found that the principal factors for explaining microemulsion structure changes are surfactant shape, entropic energy terms, as well as solvent properties as ionic force and ph. The composition of microemulsion and swollen micelle were the same as in fig. A model pseudoternary phase diagram, with the region of existence of ow me, wo me micelles, reverse micelles, and bicontinuous twophase system with three corners representing oil, water, and surfactant. Simultaneous study of molecular and micelle diffusion in. Some basics related to micro emulsion micelle reverse micelle 9 10. A potential novel drug delivery system jaspreet kaur saini 1, ujjwal nautiyal 1, senthil kumar m 1, devendra singh 2, firoz anwar 3 1department of pharmaceutics, himachal institute of pharmacy, paonta sahib, himachal pradesh, india.
An oilinwater microemulsion is a thermodynamically stable colloidal dispersion consisting of small spheroid particles comprised of oil, surfactant, and possibly cosurfactant dispersed. Molecular thermodynamic modeling of reverse micelles and. Comparison of microstructures of microemulsion and swollen. Microemulsionfoam interactions are significant in the low tension gas process, an emerging enhanced oil recovery method. Microemulsion is defined as microemulsion are clear, transparent, thermodynamically stable dispersions of oil and water, stabilized by an interfacial film of surfactant frequently in combination with a cosurfactant 2. Microemulsion is a transparent, isotropic and thermodynamically stable preparation. Types and concentrations of surfactants tween 20, 40, 60 and 80 and oils sunflower oil, lemon oil, tributyrin, isopropyl myristate and imwitor 308 were investigated for their influence on the solubilisation of oil molecules from emulsion droplets into surfactant micelles, thus the formation of nano. In general ow microemulsion wo reverse microemulsion if the medium is free of oil then aggregates are very small, while the presence of oil makes large surfactant aggregates in general, all microemulsions are made of swollen micelles with oilwater inside them. Peo ppo peo stabilized oilinwater microemulsions langmuir, vol.
May 30, 2015 some basics related to micro emulsion micelle reverse micelle 9 10. Microemulsion technology is applied in the cosmetic and pharmaceutical industry in the formulation of transdermal drug delivery systems and some topical preparations because of their potential to increase the permeation of drug across diffusion layers, good appearance, and. In the present work, typical microemulsion containing 0. These processes can be described with a molecular and a. Exxon research and engineering company, corporate research laboratories, linden. Pdf micelles, vesicles and microemulsions researchgate. The microemulsion system thus, shows a structural change from oil continuous system to water continuous, which has higher viscosities than the former 34. The solvent originally solubilized in a microemulsion droplet, penetrates the thin film of oil. Micelle dimensions fitted parameters 0% 65% 100% avg radius a 160 stdev a 50 70 particle size distribution model predictions to within the accuracy of the predicted particle size distributions, the polymer particles are not swollen by monomer. Microemulsions is defined as transparent dispersion consisting of, oil surfactant cosurfactant water omega college of. May 25, 2018 microemulsionfoam interactions are significant in the low tension gas process, an emerging enhanced oil recovery method. The surfactant deposits on the interface between the aqueous phase and the oil, thereby reducing its interfacial tension.
Preparation of nano and microemulsions using phase inversion. From oilswollen wormlike micelles to microemulsion droplets. Microemulsion formulations have distinct advantages over macroemulsion systems when delivered parenterally because of the fine particle microemulsion is cleared more slowly than the coarse particle emulsion and, therefore, have a longer residence time in the body. Generally, two approaches have been considered in the description of microemulsion systems, to have them considered as higher swollen micelles or to involve changes that occur at the ow interface. From oilswollen wormlike micelles to microemulsion. Formulation optimization of reverse microemulsions using. Based on our results, we believe that microemulsions can be considered as swollen micelles, but all micellar solutions cannot be swollen to the extent of. Characterization of microemulsions prepared using isopropyl. More confusingly still, the term microemulsion can refer to the single. Drug solubilization capacity of the microemulsion system was determined. Microemulsion technology is applied in the cosmetic and pharmaceutical industry in the formulation of transdermal drug delivery systems and some topical preparations because of their potential to increase the permeation of drug.
Oil and water are immiscible and they separate into two phases when mixed, each saturated with traces of the other component capek, 1999. Lipixelle tm technology is a platform for solubilizing ophthalmic drugs with limited water solubility or completely insoluble ophthalmic drugs the currently marketed latanoprost eye drops contain benzalkonium chloride bak. We seek for conditions where the microemulsion is close to but below the line of emulsification failure. Xelpros tm is developed using sparcs proprietary swollen micelle microemulsion smm technology, which helps to solubilize ophthalmic drugs that have limited water solubility or no solubility thus eliminating the need for quaternary ammonium preservative surfactant benzalkonium chloride bak, which may be damaging. Microemulsion formation and stability can be explained on the basis of a simplified thermodynamic rationalization. When diluted, the rate of oil uptake by the microemulsion is orders of magnitude smaller than for the swollen micelles. A microemulsion is an emulsion which forms spontaneously, without mechanical action, from a mixture of two liquid phases under certain conditions. While the determination of molecular diffusion coefficients of gases dissolved in various kinds of liquids. Pdf a theory of selfassembly of surfactant molecules into micelles and bilayers is.
Formulation and characterization of microemulsion system. Micro emulsions are dispersed, macroscopically homogeneous, thermodynamically stable, optically transparent, singlephase systems, formed by the spontaneous solubilisation of two otherwise immiscible liquids, in the presence of surfactants. The microstructure of the ternary system pentaethyleneglycol monododecyl ether c12e5, decane and water was investigated by static light scattering in the waterrich region of the phase diagram at constant temperature 22 c. Overall, understanding the properties of swollen micelles and how they transform to microemulsions not only provide theoretical support for practical applications of surfactants, but can also be used to design new surfactants. Microemulsions were probably discovered well before the studies of schulmann. The microemulsion 30 is here a thermodynamically stable dispersion in brine of oil droplets surrounded by a surfactant film. The swollen micellemicroemulsion transition sciencedirect. Although not systematically used today, some prefer the names micellar emulsion 5 or swollen micelles 6. More confusingly still, the term microemulsion can refer to the single isotropic phase that is a mixture of oil, water and surfactant, or to one that is in equilibrium with coexisting predominantly oil and. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of. A typical micelle in aqueous solution forms an aggregate with the hydrophilic head regions in contact with surrounding solvent, sequestering.
What is the difference between swollen micelle and micro. Types and concentrations of surfactants tween 20, 40, 60 and 80 and oils sunflower oil, lemon oil, tributyrin, isopropyl myristate and imwitor 308 were investigated for their influence on the solubilisation of oil molecules from emulsion droplets into surfactant micelles, thus the formation of nano and microemulsion. In this paper we examine the effective interactions introduced between the droplets of an oil in water microemulsion upon progressive addition of hydrophobically. The swollen micelle microemulsion transition donald b. It has been found that the principal factors for explaining microemulsion structure changes are surfactant shape, entropic energy terms, as. Micelles, microemulsions, liquid crystals, and the. Bak is a common preservative in topical ocular preparations. The line of emulsification failure is the limit above which the. Australian housewives have used since the beginning of last century. Alternative names for these systems are often used, such as transparent emulsion, swollen micelle, micellar solution, and solubilized oil. Developed with sparcs swollen micelle microemulsion technology.
As oilwatersurfactant systems are subjected to various salinity environments and microemulsion phase behavior varies, foam strength has also been observed to vary. This decrease of m w is due to a transition from elongated wormlike micelles to microemulsion droplets. Both ow and wo microemulsion can be used for parenteral delivery. Shulman, professors of chemistry at cambridge university, in 1943. Xelpros, latanoprost ophthalmic emulsion product profile.
A microemulsion is an emulsion which forms spontaneously, without mechanical action, from a mixture of two liquid phases under certain conditions surfactant concentration, salt content, temperature. Accelerated stability study of the developed microemulsion was carried out for 6 months. One of the most important fundamental questions in this eld is the relation between the properties of the surfactant monolayer at wateroil interface and those of microemulsions. Emulsions part 3 microemulsions miniemulsions remarks to. A very similar model was recently proposed by mendizabal et al. Micelles may be swollen by oils to a generally limited extent of the order of one oil molecule per surfactant molecule.
R w and r o denote the size of the aqueous core and the micelle, respectively. As the oil increases, it can be called swollen micelles, then microemulsions, etc. So far as physics rather than industrial processes is concerned micelles and microemulsion can be considered as synonyms. Micelles, microemulsions, liquid crystals, and the structure. Microemulsions are also called as, transparent emulsion swollen micelle micellar solution solubilized oil omega college of pharmacy. Fluorescence spectrums of pyrene in microemulsion and swollen micelle. A typical micelle in aqueous solution forms an aggregate with the hydrophilic head regions in contact with surrounding solvent, sequestering the hydrophobic singletail regions in the. Decrease in micelle availability and micellar structuring effectiveness, with interaction. Glimepiride loaded microemulsion using labrafil m 1944 cs, cremophor rh 40, transcutol p as oil, surfactant and cosurfactant respectively, was prepared and characterized. Micellar size and shape were determined along several pseudobinary sections of constant oiltosurfactant ratio. Preparation of nano and microemulsions using phase. Once the cosurfactant is added, the solubilising power can become infinite.
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